1 HAEMATOPOIESIS: MORPHOLOGICAL CHARACTERISATION OF THE MATURING AND DIFFERENTIATED CELLULAR COMPONENT OF HAEMATOPOIESIS
2 BLOOD CELLS ASSESSMENT
2.1 Erytrocyte morphology
2.2 White cell assessment
2.3 Megakaryocyte and Platelet assessment
(10)2.4 Apoptotic cells in the peripheral blood smear
(0)2.5 Artefacts in peripheral blood smears
(0)3 ANAEMIA (EXCEPT FOR APLASTIC ANAEMIA)
3.1 Iron deficiency anaemia and megaloblastic anaemia
3.2 Haemolytic anaemia
3.3 Congenital haemolytic anaemia due to membrane defects
3.4 Congenital disorders affecting erythrocyte membrane permeability
3.5 Abnormalities in red cell antigens
3.6 Hereditary red cell enzyme deficiencies
(4)3.7 Structural variants of haemoglobin
3.8 Thalassaemias
3.9 Unstable haemoglobins
(3)3.10 Haemoglobins with altered oxygen affinity
(0)3.11 Congenital dyserythropoietic anaemia
3.12 Congenital sideroblastic anaemia
(1)4 BONE MARROW FAILURE: APLASTIC ANAEMIA, ERYTHROBLASTOPENIA, AMEGAKARYOCYTOSIS, AGRANULOCYTOSIS, NEUTROPENIA. CYCLIC HAEMATOPOIESIS
5 MYELOPROLIFERATIVE NEOPLASMS
6 MASTOCYTOSIS
7 MYELOID/LYMPHOID NEOPLASMS WITH EOSINOPHILIA AND REARRANGEMENT OF PDGFRA, PDGFRB, OR FGFR1, OR WITH PCM1-JAK2
8 MYELODYSPLASTIC SYNDROMES
9 MYELODYSPLASTIC SYNDROMES (MDS)
9.1 Myelodysplastic syndromes (MDS)
9.2 Classification of myelodysplastic syndromes (MDS)
9.2.1 Myelodysplastic syndrome with single lineage dysplasia
(1)9.2.2 Myelodysplastic syndrome with multilineage lineage dysplasia
(1)9.2.3 Myelodysplastic syndrome with ring sideroblasts (MDS-RS)
(9)9.2.4 Myelodysplastic syndrome with excess blasts (EB-1,EB-2)
(15)9.2.5 Myelodysplastic syndrome with isolated del(5q)
(14)9.2.6 Myelodysplastic syndrome, unclassifiable
(1)9.2.7 Provisional entity: Refractory cytopenia of childhood
(3)10 ACUTE MYELOID LEUKAEMIA (AML) AND RELATED NEOPLASMS
10.1 AML with recurrent genetic abnormalities
10.1.1 AML with t(8;21)(q22;q22.1); RUNX1-RUNX1T1
(5)10.1.2 AML with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11
(19)10.1.3 APL with PML-RARA
(22)10.1.4 AML with t(9;11)(p21.3;q23.3); MLLT3-KMT2A
(10)10.1.5 AML with t(6;9)(p23;q34.1); DEK-NUP214
(3)10.1.6 AML with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2); GATA2, MECOM
(3)10.1.7 AML (megakaryoblastic) with t(1;22)(p13.3;q13.3); RBM15-MKL1
(0)10.1.8 Provisional entity: AML with BCR-ABL1
(0)10.1.9 AML with mutated NPM1
(7)10.1.10 AML with biallelic mutations of CEBPA
(1)10.1.11 Provisional entity: AML with mutated RUNX1
(0)10.2 AML with myelodysplasia-related changes
(15)10.3 Therapy-related myeloid neoplasms
(15)10.4 AML, NOS
10.4.1 AML with minimal differentiation
(2)10.4.2 AML without maturation
(6)10.4.3 AML with maturation
(8)10.4.4 Acute myelomonocytic leukaemia
(9)10.4.5 Acute monoblastic/monocytic leukaemia
(10)10.4.6 Pure erythroid leukaemia
(19)10.4.7 Acute megakaryoblastic leukaemia
(10)10.4.8 Acute basophilic leukaemia
(0)10.4.9 Acute panmyelosis with myelofibrosis
(4)10.5 Myeloid sarcoma
(5)10.6 Myeloid proliferations related to Down syndrome
11 BLASTIC PLASMACYTOID DENDRITIC CELL NEOPLASM
(13)12 ACUTE LEUKAEMIAS OF AMBIGUOUS LINEAGE
12.1 Acute undifferentiated leukaemia
(0)12.2 Mixed phenotype acute leukaemia with t(9;22)(q34.1;q11.2); BCR-ABL1
(2)12.3 Mixed phenotype acute leukaemia with t(v;11q23.3); KMT2A rearranged
(0)12.4 Mixed phenotype acute leukaemia , B/myeloid, NOS
(1)12.5 Mixed phenotype acute leukaemia, T/myeloid, NOS
(1)12.6 Mixed-phenotype acute leukaemia, NOS, rare subtypes
(0)12.7 Acute leukaemia of ambiguous lineage, NOS
(0)13 B-LYMPHOBLASTIC LEUKAEMIA/LYMPHOMA
13.1 B-lymphoblastic leukaemia/lymphoma, NOS
(6)13.2 B-lymphoblastic leukaemia/lymphoma with recurrent genetic abnormalities
13.2.1 B-lymphoblastic leukaemia/lymphoma with t(9;22)(q34.1;q11.2); BCR-ABL1
(7)13.2.2 B-lymphoblastic leukaemia/lymphoma with t(v;11q23.3); KMT2A rearranged
(1)13.2.3 B-lymphoblastic leukaemia/lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1
(0)13.2.4 B-lymphoblastic leukaemia/lymphoma with hyperdiploidy
(0)13.2.5 B-lymphoblastic leukaemia/lymphoma with hypodiploidy
(0)13.2.6 B-lymphoblastic leukaemia/lymphoma with t(5;14)(q31.1;q32.3) IGH/IL3
(0)13.2.7 B-lymphoblastic leukaemia/lymphoma with t(1;19)(q23;p13.3); TCF3-PBX1
(0)13.2.8 Provisional entity: B-lymphoblastic leukaemia/lymphoma, BCR-ABL1–like
(0)13.3 T-lymphoblastic leukaemia/lymphoma
(19)13.4 Provisional entity: Natural killer (NK) cell lymphoblastic leukaemia/lymphoma
(0)13.4 Provisional entity: Natural killer (NK) cell lymphoblastic leukaemia/lymphoma
(0)14 MATURE B-CELL NEOPLASMS
14.1 Chronic lymphocytic leukaemia/small lymphocytic lymphoma
(12)14.2 B-cell prolymphocytic leukaemia
(4)14.3 Splenic marginal zone lymphoma
(4)14.4 Hairy cell leukaemia
(9)14.5 Splenic B-cell lymphoma/leukaemia, unclassifiable
14.6 Lymphoplasmacytic lymphoma
(2)14.7 Monoclonal gammopathy of undetermined significance (MGUS), IgM
(0)14.8 Heavy-chain diseases
14.9 Plasma cell neoplasms
14.9.1 Monoclonal gammopathy of undetermined significance (MGUS), IgG/A
(1)14.9.2 Plasma cell myeloma
(49)14.9.3 Plasma cell myeloma variants
14.9.4 Solitary plasmacytoma of bone
(0)14.9.5 Extraosseous plasmacytoma
(2)14.9.6 Monoclonal immunoglobulin deposition diseases
14.9.7 Plasma cell neoplasms with associated paraneoplastic syndrome
14.10 Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)
(0)14.11 Nodal marginal zone lymphoma
(0)14.12 Follicular lymphoma
(5)14.13 Pediatric-type follicular lymphoma
(0)14.14 Large B-cell lymphoma with IRF4 rearrangement
(0)14.15 Primary cutaneous follicle center lymphoma
(0)14.16 Mantle cell lymphoma
(11)14.17 Diffuse large B-cell lymphoma (DLBCL), NOS
(1)14.18 T-cell/histiocyte-rich large B-cell lymphoma
(0)14.19 Primary DLBCL of the central nervous system (CNS)
(0)14.20 Primary cutaneous DLBCL, leg type
(0)14.21 EBV-positive DLBCL, NOS
(0)14.22 EBV-positive mucocutaneous ulcer
(0)14.23 DLBCL associated with chronic inflammation
(0)14.24 Lymphomatoid granulomatosis
(0)14.25 Primary mediastinal (thymic) large B-cell lymphoma
(0)14.26 Intravascular large B-cell lymphoma
(0)14.27 ALK1 large B-cell lymphoma
(0)14.28 Plasmablastic lymphoma
(5)14.29 Primary effusion lymphoma
(2)14.30 HHV81 DLBCL, NOS
(0)14.31 Burkitt lymphoma
(7)14.32 Burkitt-like lymphoma with 11q aberration
(0)14.33 High-grade B-cell lymphoma
14.34 B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classical Hodgkin lymphoma
(0)15 MATURE T AND NK NEOPLASMS
15.1 T-cell prolymphocytic leukaemia
(3)15.2 T-cell large granular lymphocytic leukaemia
(7)15.3 Chronic lymphoproliferative disorder of NK cells
(0)15.4 Aggressive NK-cell leukaemia
(3)15.5 Systemic EBV1 T-cell lymphoma of childhood
(0)15.6 Adult T-cell leukaemia/lymphoma
(5)15.7 Extranodal NK-/T-cell lymphoma, nasal type
(4)15.8 Enteropathy-associated T-cell lymphoma
(0)15.9 Hepatosplenic T-cell lymphoma
(0)15.10 Subcutaneous panniculitis-like T-cell lymphoma
(0)15.11 Mycosis fungoides
(0)15.12 Sézary syndrome
(7)15.13 Primary cutaneous CD30-positive T-cell lymphoproliferative disorders
(0)15.14 Primary cutaneous and peripheral T-cell lymphoma, rare subtypes
(0)15.15 Peripheral T-cell lymphoma, NOS
(0)15.16 Angioimmunoblastic T-cell lymphoma and nodal peripheral T-cell lymphoma with T-follicular helper phenotype
(1)15.17 Anaplastic large-cell lymphoma, ALK positive
(6)15.18 Anaplastic large-cell lymphoma, ALK negattive
(1)15.19 Breast implant–associated anaplastic large-cell lymphoma
(0)16 HODGKIN LYMPHOMA
17 IMMUNODEFICIENCY-ASSOCIATED LYMPHOPROLIFERATIVE DISORDERS
17.1 Primary immunodeficiency-associated lymphoproliferative disorders
(0)17.2 Lymphoid Proliferations Associated With Human Immunodeficiency Virus Infection
(2)17.3 Post-transplant lymphoproliferative disorders (PTLD)
(4)17.4 Other iatrogenic immunodeficiency-associated lymphoproliferative disorder
(0)18 INFECTIOUS MONONUCLEOSIS AND RELATED SYNDROMES. LYMPHOCYTIC AND GRANULOCYTIC LEUKAEMOID REACTIONS. PERSISTENT POLYCLONAL B-CELL LYMPHOCYTOSIS
19 HISTIOCYTIC AND DENDRITIC CELL NEOPLASMS
19.1 Histiocytic sarcoma
(0)19.2 Langerhans cells neoplasms
19.3 Indeterminate dendritic cell tumor
(0)19.4 Interdigitating dendritic cell sarcoma
(0)19.5 Follicular dendritic cell sarcoma
(0)19.6 Fibroblastic reticular cell tumor
(0)19.7 Disseminated juvenile xanthogranuloma
(0)19.8 Erdheim-Chester disease
(2)20 MONONUCLEAR-PHAGOCYTIC SYSTEM
21 CYTOMORPHOLOGY EVALUATION AND CONTRIBUTION TO THE DIAGNOSIS OF NON-HAEMATOLOGIC DISEASES
22 MISCELLANEOUS DISORDERS
(1)