Atlas categories

1 HAEMATOPOIESIS: MORPHOLOGICAL CHARACTERISATION OF THE MATURING AND DIFFERENTIATED CELLULAR COMPONENT OF HAEMATOPOIESIS
- 1.1 Myelopoiesis
- 1.2 Lymphopoiesis
2 BLOOD CELLS ASSESSMENT
- 2.1 Erytrocyte morphology
- 2.2 White cell assessment
  - 2.2.1 Polymorphonuclear neutrophils
    - 2.2.1.1 Alterations in nuclear morphology
      (1)
    - 2.2.1.2 Alterations in cytoplasmic morphology
      (5)
  - 2.2.2 Lymphocytes
    - 2.2.2.1 Nuclear features
      (0)
    - 2.2.2.2 Cytoplasmic features
      (2)
  - 2.2.3 Plasma cells
    (3)
  - 2.2.4 Monocytes
    (2)
  - 2.2.5 Intracellular parasites
    (0)
  - 2.2.6 Morphological abnormalities due to granulocyte colony-stimulating factor (G-CSF) treatment
    (2)
- 2.3 Platelet assessment
  (6)
- 2.4 Apoptotic cells in the peripheral blood smear
  (0)
- 2.5 Artefacts in peripheral blood smears
  (0)
3 ANAEMIA (EXCEPT FOR APLASTIC ANAEMIA)
- 3.1 Iron deficiency anaemia and megaloblastic anaemia
  - 3.1.1 Iron deficiency anaemia
    (2)
  - 3.1.2 Megaloblastic anaemia
    (10)
- 3.2 Haemolytic anaemia
  - 3.2.1 Acquired haemolytic anaemia
    (12)
  - 3.2.2 Paroxysmal nocturnal haemoglobinuria
    (3)
- 3.3 Congenital haemolytic anaemia due to membrane defects
  - 3.3.1 Hereditary spherocytosis
    (2)
  - 3.3.2 Hereditary elliptocytosis
    (3)
- 3.4 Congenital disorders affecting erythrocyte membrane permeability
  - 3.4.1 Hereditary xerocytosis
    (3)
  - 3.4.2 Hereditary hydrocytosis
    (0)
- 3.5 Abnormalities in red cell antigens
- 3.6 Hereditary red cell enzyme deficiencies
  (3)
- 3.7 Structural variants of haemoglobin
  - 3.7.1 Sickle cell disease
    (12)
  - 3.7.2 Hb C disease
    (4)
- 3.8 Thalassaemias
  - 3.8.1 β-thalassaemia
  - 3.8.2 α-thalassaemia
    (2)
- 3.9 Unstable haemoglobins
  (3)
- 3.10 Haemoglobins with altered oxygen affinity
  (0)
- 3.11 Congenital dyserythropoietic anaemia
- 3.12 Congenital sideroblastic anaemia
  (1)
4 BONE MARROW FAILURE: APLASTIC ANAEMIA, ERYTHROBLASTOPENIA, AMEGAKARYOCYTOSIS, AGRANULOCYTOSIS, NEUTROPENIA. CYCLIC HAEMATOPOIESIS
- 4.1 Bone marrow failure
- 4.2 Partial bone marrow failure
  - 4.2.1 Erythroblastopenia
    (3)
  - 4.2.2 Agranulocytosis and neutropenia
    - 4.2.2.1 Agranulocytosis
      (1)
    - 4.2.2.2 Neutropenia
      - 4.2.2.2.1 Primary neutropenia
        (0)
      - 4.2.2.2.2 Secondary neutropenia
        (0)
  - 4.2.3 Pseudoneutropenia
    (2)
- 4.3 Thrombocytopenia
- 4.4 Cyclic hematopoiesis
  (0)
5 MYELOPROLIFERATIVE NEOPLASMS
- 5.1 Chronic myeloid leukaemia BCR-ABL1 positive
  (15)
- 5.2 Chronic neutrophilic leukaemia
  (0)
- 5.3 Polycythemia vera
  (7)
- 5.4 Primary myelofibrosis
  (19)
- 5.5 Essential thrombocythaemia
  (4)
- 5.6 Chronic eosinophilic leukaemia
  (2)
- 5.7 MPN, unclassifiable
  (0)
6 MASTOCYTOSIS
- 6.1 Cutaneous mastocytosis
  (0)
- 6.2 Systemic mastocytosis
  (22)
- 6.3 Mast cell sarcoma
  (0)
7 MYELOID/LYMPHOID NEOPLASMS WITH EOSINOPHILIA AND REARRANGEMENT OF PDGFRA, PDGFRB, OR FGFR1, OR WITH PCM1-JAK2
- 7.1 Myeloid/lymphoid neoplasms with PDGFRA rearrangement
  (1)
- 7.2 Myeloid/lymphoid neoplasms with PDGFRB rearrangement
  (0)
- 7.3 Myeloid/lymphoid neoplasms with FGFR1 rearrangement
  (0)
- 7.4 Provisional entity: Myeloid/lymphoid neoplasms with PCM1-JAK2
  (0)
8 MYELODYSPLASTIC SYNDROMES
- 8.1 Chronic myelomonocytic leukaemia
  (6)
- 8.2 Atypical chronic myeloid leukaemia (aCML), BCR-ABL1 negative
  (6)
- 8.3 Juvenile myelomonocytic leukaemia
  (9)
- 8.4 MDS/MPN with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T)
  (7)
- 8.5 MDS/MPN, unclassifiable
  (0)
9 MYELODYSPLASTIC SYNDROMES (MDS)
- 9.1 Myelodysplastic syndromes (MDS)
  - 9.1.1 Assessment of dysplasia
- 9.2 Classification of myelodysplastic syndromes (MDS)
  - 9.2.1 Myelodysplastic syndrome with single lineage dysplasia
    (1)
  - 9.2.2 Myelodysplastic syndrome with multilineage lineage dysplasia
    (0)
  - 9.2.3 Myelodysplastic syndrome with ring sideroblasts (MDS-RS)
    - 9.2.3.1 Myelodysplastic syndrome and single lineage dysplasia
      (0)
    - 9.2.3.2 Myelodysplastic syndrome with ring sideroblasts and multilineage dysplasia
      (1)
  - 9.2.4 Myelodysplastic syndrome with excess blasts (EB-1,EB-2)
    - 9.2.4.1 Myelodysplastic syndrome with excess blasts-1
      (1)
    - 9.2.4.2 Myelodysplastic syndrome with excess blasts-2
      (1)
  - 9.2.5 Myelodysplastic syndrome with isolated del(5q)
    (14)
  - 9.2.6 Myelodysplastic syndrome, unclassifiable
    (1)
  - 9.2.7 Provisional entity: Refractory cytopenia of childhood
    (3)
10 ACUTE MYELOID LEUKAEMIA (AML) AND RELATED NEOPLASMS
- 10.1 AML with recurrent genetic abnormalities
- 10.2 AML with myelodysplasia-related changes
  (14)
- 10.3 Therapy-related myeloid neoplasms
  (14)
- 10.4 AML, NOS
- 10.5 Myeloid sarcoma
  (5)
- 10.6 Myeloid proliferations related to Down syndrome
  - 10.6.1 Transient abnormal myelopoiesis (TAM)
    (1)
  - 10.6.2 Myeloid leukaemia associated with Down síndrome
    (1)
11 BLASTIC PLASMACYTOID DENDRITIC CELL NEOPLASM
(13)
12 ACUTE LEUKAEMIAS OF AMBIGUOUS LINEAGE
- 12.1 Acute undifferentiated leukaemia
  (0)
- 12.2 Mixed phenotype acute leukaemia with t(9;22)(q34.1;q11.2); BCR-ABL1
  (2)
- 12.3 Mixed phenotype acute leukaemia with t(v;11q23.3); KMT2A rearranged
  (0)
- 12.4 Mixed phenotype acute leukaemia , B/myeloid, NOS
  (0)
- 12.5 Mixed phenotype acute leukaemia, T/myeloid, NOS
  (1)
- 12.6 Mixed-phenotype acute leukaemia, NOS, rare subtypes
  (0)
- 12.7 Acute leukaemia of ambiguous lineage, NOS
  (0)
13 B-LYMPHOBLASTIC LEUKAEMIA/LYMPHOMA
- 13.1 B-lymphoblastic leukaemia/lymphoma, NOS
  (6)
- 13.2 B-lymphoblastic leukaemia/lymphoma with recurrent genetic abnormalities
- 13.3 T-lymphoblastic leukaemia/lymphoma
  - 13.3.1 Provisional entity: Early T-cell precursor lymphoblastic leukaemia
    (0)
- 13.4 Provisional entity: Natural killer (NK) cell lymphoblastic leukaemia/lymphoma
  (0)
- 13.4 Provisional entity: Natural killer (NK) cell lymphoblastic leukaemia/lymphoma
  (0)
14 MATURE B-CELL NEOPLASMS
- 14.1 Chronic lymphocytic leukaemia/small lymphocytic lymphoma
  - 14.1.1 Monoclonal B-cell lymphocytosis
    (0)
- 14.2 B-cell prolymphocytic leukaemia
  (3)
- 14.3 Splenic marginal zone lymphoma
  (4)
- 14.4 Hairy cell leukaemia
  (9)
- 14.5 Splenic B-cell lymphoma/leukaemia, unclassifiable
  - 14.5.1 Splenic diffuse red pulp small B-cell lymphoma
    (0)
  - 14.5.2 Hairy cell leukaemia-variant
    (4)
- 14.6 Lymphoplasmacytic lymphoma
  - 14.6.1 Waldenström macroglobulinemia
    (0)
- 14.7 Monoclonal gammopathy of undetermined significance (MGUS), IgM
  (0)
- 14.8 Heavy-chain diseases
  - 14.8.1 ɣ heavy-chain disease
    (0)
  - 14.8.2 µ heavy-chain disease
    (0)
  - 14.8.3 α heavy-chain disease
    (0)
- 14.9 Plasma cell neoplasms
  - 14.9.1 Monoclonal gammopathy of undetermined significance (MGUS), IgG/A
    (1)
  - 14.9.2 Plasma cell myeloma
    (42)
  - 14.9.3 Plasma cell myeloma variants
  - 14.9.4 Solitary plasmacytoma of bone
    (0)
  - 14.9.5 Extraosseous plasmacytoma
    (2)
  - 14.9.6 Monoclonal immunoglobulin deposition diseases
    - 14.9.6.1 Primary amyloidosis
      (1)
    - 14.9.6.2 Light chain and heavy chain deposition diseases
      (0)
  - 14.9.7 Plasma cell neoplasms with associated paraneoplastic syndrome
    - 14.9.7.1 POEMS syndrome
      (0)
    - 14.9.7.2 TEMPI syndrome
      (0)
- 14.10 Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)
  (0)
- 14.11 Nodal marginal zone lymphoma
  (0)
- 14.12 Follicular lymphoma
  (5)
- 14.13 Pediatric-type follicular lymphoma
  (0)
- 14.14 Large B-cell lymphoma with IRF4 rearrangement
  (0)
- 14.15 Primary cutaneous follicle center lymphoma
  (0)
- 14.16 Mantle cell lymphoma
  (10)
- 14.17 Diffuse large B-cell lymphoma (DLBCL), NOS
  (0)
- 14.18 T-cell/histiocyte-rich large B-cell lymphoma
  (0)
- 14.19 Primary DLBCL of the central nervous system (CNS)
  (0)
- 14.20 Primary cutaneous DLBCL, leg type
  (0)
- 14.21 EBV-positive DLBCL, NOS
  (0)
- 14.22 EBV-positive mucocutaneous ulcer
  (0)
- 14.23 DLBCL associated with chronic inflammation
  (0)
- 14.24 Lymphomatoid granulomatosis
  (0)
- 14.25 Primary mediastinal (thymic) large B-cell lymphoma
  (0)
- 14.26 Intravascular large B-cell lymphoma
  (0)
- 14.27 ALK1 large B-cell lymphoma
  (0)
- 14.28 Plasmablastic lymphoma
  (5)
- 14.29 Primary effusion lymphoma
  (2)
- 14.30 HHV81 DLBCL, NOS
  (0)
- 14.31 Burkitt lymphoma
  (7)
- 14.32 Burkitt-like lymphoma with 11q aberration
  (0)
- 14.33 High-grade B-cell lymphoma
  - 14.33.1 High-grade B-cell lymphoma, with MYC and BCL2 and/or BCL6 rearrangements
    (1)
  - 14.33.2 High-grade B-cell lymphoma, NOS
    (0)
- 14.34 B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classical Hodgkin lymphoma
  (0)
15 MATURE T AND NK NEOPLASMS
- 15.1 T-cell prolymphocytic leukaemia
  (3)
- 15.2 T-cell large granular lymphocytic leukaemia
  (7)
- 15.3 Chronic lymphoproliferative disorder of NK cells
  (0)
- 15.4 Aggressive NK-cell leukaemia
  (3)
- 15.5 Systemic EBV1 T-cell lymphoma of childhood
  (0)
- 15.6 Adult T-cell leukaemia/lymphoma
  (5)
- 15.7 Extranodal NK-/T-cell lymphoma, nasal type
  (4)
- 15.8 Enteropathy-associated T-cell lymphoma
  (0)
- 15.9 Hepatosplenic T-cell lymphoma
  (0)
- 15.10 Subcutaneous panniculitis-like T-cell lymphoma
  (0)
- 15.11 Mycosis fungoides
  (0)
- 15.12 Sézary syndrome
  (7)
- 15.13 Primary cutaneous CD30-positive T-cell lymphoproliferative disorders
  (0)
- 15.14 Primary cutaneous and peripheral T-cell lymphoma, rare subtypes
  (0)
- 15.15 Peripheral T-cell lymphoma, NOS
  (0)
- 15.16 Angioimmunoblastic T-cell lymphoma and nodal peripheral T-cell lymphoma with T-follicular helper phenotype
  (1)
- 15.17 Anaplastic large-cell lymphoma, ALK positive
  (6)
- 15.18 Anaplastic large-cell lymphoma, ALK negattive
  (1)
- 15.19 Breast implant–associated anaplastic large-cell lymphoma
  (0)
16 HODGKIN LYMPHOMA
- 16.1 Nodular lymphocyte predominant Hodgkin lymphoma
  (0)
- 16.2 Classical Hodgkin lymphoma
17 IMMUNODEFICIENCY-ASSOCIATED LYMPHOPROLIFERATIVE DISORDERS
- 17.1 Primary immunodeficiency-associated lymphoproliferative disorders
  (0)
- 17.2 Lymphoid Proliferations Associated With Human Immunodeficiency Virus Infection
  (2)
- 17.3 Post-transplant lymphoproliferative disorders (PTLD)
  (4)
- 17.4 Other iatrogenic immunodeficiency-associated lymphoproliferative disorder
  (0)
18 INFECTIOUS MONONUCLEOSIS AND RELATED SYNDROMES. LYMPHOCYTIC AND GRANULOCYTIC LEUKAEMOID REACTIONS. PERSISTENT POLYCLONAL B-CELL LYMPHOCYTOSIS
- 18.1 Infectious mononucleosis
  (3)
- 18.2 Leukaemoid reactions
- 18.3 Persistent polyclonal B-cell lymphocytosis
  (7)
19 HISTIOCYTIC AND DENDRITIC CELL NEOPLASMS
- 19.1 Histiocytic sarcoma
  (0)
- 19.2 Langerhans cells neoplasms
  - 19.2.1 Langerhans cell histiocytosis
    (0)
  - 19.2.2 Langerhans cell sarcoma
    (2)
- 19.3 Indeterminate dendritic cell tumor
  (0)
- 19.4 Interdigitating dendritic cell sarcoma
  (0)
- 19.5 Follicular dendritic cell sarcoma
  (0)
- 19.6 Fibroblastic reticular cell tumor
  (0)
- 19.7 Disseminated juvenile xanthogranuloma
  (0)
- 19.8 Erdheim-Chester disease
  (2)
20 MONONUCLEAR-PHAGOCYTIC SYSTEM
- 20.1 Reactive histiocytosis with or without prominent haemophagocytosis
- 20.2 Familial haemophagocytic lymphohistiocytosis
  (0)
- 20.3 Histiocytosis asociated to metabolic disorders
  - 20.3.1 Gaucher disease
    (8)
  - 20.3.2 Congenital lipid histiocytosis with foamy histiocytes
    - 20.3.2.1 Niemann-Pick disease
      (1)
    - 20.3.2.2 Sea-blue histiocyte syndrome
      (0)
  - 20.3.3 Crystal-storing histiocytosis
    (0)
  - 20.3.4 Storage diseases with related blood cell abonormalities
    (1)
21 CYTOMORPHOLOGY EVALUATION AND CONTRIBUTION TO THE DIAGNOSIS OF NON-HAEMATOLOGIC DISEASES
- 21.1 Neoplastic diseases
  (24)
- 21.2 Infectious diseases
- 21.3 Anaemia of chronic disease
  (3)
- 21.4 Connective tissue diseases
  (4)
- 21.5 Other disorders (endocrine, gastrointestinal , liver and renal disease)
  (1)
- 21.6 Mental disorders
  (1)
- 21.7 Other non-haematologic diseases
  (1)
22 MISCELLANEOUS DISORDERS
(1)

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$Refractory sideroblastic anaemia with thrombocytosis$